In which neurological disorder is the accumulation of amyloid plaques characteristic?

The accumulation of amyloid plaques is most characteristic of Alzheimer’s disease. In this condition, the abnormal buildup of beta-amyloid peptides in the brain contributes to the neurodegenerative processes that result in cognitive decline and memory loss. These plaques interfere with cell-to-cell signaling and trigger inflammatory processes that may lead to further neuronal damage.

Alzheimer’s disease is marked not just by amyloid plaques, but also by neurofibrillary tangles, inflammation, and loss of synapses and neurons. This combination of factors contributes to the progressive nature of the disease, ultimately affecting various cognitive functions. Understanding the role of amyloid plaques is crucial in both the diagnosis and exploration of potential therapeutic approaches aimed at managing or preventing the progression of Alzheimer’s disease.