What is the primary characteristic of Huntington’s disease?

The primary characteristic of Huntington’s disease is the progressive degeneration of neurons, particularly in certain areas of the brain such as the basal ganglia. This degeneration leads to a variety of neurological symptoms, including motor dysfunction, cognitive decline, and psychiatric issues. As the disease progresses, the loss of these neurons becomes more pronounced, resulting in the hallmark movement disorders associated with Huntington’s disease, such as chorea, which involves involuntary movements.

The nature of Huntington’s involves a genetic mutation that leads to the production of a toxic protein, ultimately causing the death of neurons over time. This process underpins the severity and progression of the symptoms experienced by those with the condition. Understanding this characteristic is crucial for recognizing and managing the disease, as it emphasizes the need for supportive care and therapeutic interventions aimed at addressing the consequences of neurodegeneration.